Jennifer Rubin has an excerpt from an interview with Dennis Ross, a former senior adviser to Obama.
"When the president comes in, he thinks we have a major problem with Arabs and Muslims. And he sees that as a function of the Bush administration — an image, fairly or not, that Bush was at war with Islam. So one of the ways that he wants to show that he’s going to have an outreach to the Muslim world is that he’s going to give this speech in Cairo. So he wants to reach out and show that the US is not so close to the Israelis, which he thinks also feeds this perception. That’s why there’s an impulse to do some distancing from Israel, and that’s why the settlement issue is seized in a way."
It's not news, but it is confirmation that Obama deliberately sought to alienate and distance Israel. And would have done so regardless of who was the Prime Minister of Israel.